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Dr. Mark L. Gordon has been featured with
The Millennium Health Centers - Mental Health Program
The Triad of Mental Illness
In nearly 100% of the patients with traumatic brain injury, they complain of Fatigue, Insomnia, and Depression. In looking for the mechanism which causes this Triad, what we found was: Neuroinflammation causes the destruction of two very important enzymes that are responsible for the production of Serotonin and Melatonin; L-Tryptophan Hydroxylase and L-Tryptophan Decarboxylase. Without these enzymes we cannot make the natural anti-depression neurotransmitter Serotonin which then becomes Melatonin causing insomnia. Since the Tryptophan is not converting to these chemicals, Tryptophan builds up (Thanksgiving turkey effect) initially causing fatigue. Over time, metabolites of Tryptophan become neurotoxic; Headaches, Migraines, increase pain, and further depression.